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Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca2+ dynamics

The pancreatic islet is surrounded by ECM that provides both biochemical and mechanical cues to the islet β-cell to regulate cell survival and insulin secretion. Changes in ECM composition and mechanical properties drive β-cell dysfunction in many pancreatic diseases. While several studies have char...

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Principais autores: Chelsea G. Johansen, Keifer Holcomb, Amit Sela, Stephanie Morrall, Daewon Park, Nikki L. Farnsworth
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-06-01
Serier:Matrix Biology Plus
Fag:
Pancreatic islet
Mechanotransduction
Insulin secretion
Stiffness
Extracellular matrix
Piezo1
Online adgang:http://www.sciencedirect.com/science/article/pii/S2590028524000085
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