Atrial APD prolongation caused by the upregulation of RAGE and subsequent I_NaL increase in diabetic patients

Diabetes mellitus (DM) is a risk factor for the development of atrial fibrillation (AF). The action potential duration (APD) has been demonstrated to be prolonged in the atrium of diabetic mice. In contrast, the APD is generally shortened in AF patients. It is unclear what change occurs in the atria...

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Bibliografische Detailangaben

Hauptverfasser:	Luo Yingchun, Ma Wenbo, Kang Qi, Pan Han, Shi Ling, Ma Jiudong, Song Jiahui, Gong Dongmei, Kang Kai, Jin Xuexin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	China Science Publishing & Media Ltd. 2025-03-01
Schriftenreihe:	Acta Biochimica et Biophysica Sinica
Schlagworte:	diabetes mellitus receptor for advanced glycation end products (RAGE) late sodium current action potential duration atrial fibrillation
Online-Zugang:	https://www.sciengine.com/doi/10.3724/abbs.2025018
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