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Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mice

Summary: NMDA receptor dysfunction is implicated in the pathophysiology of autism spectrum disorder (ASD). Here, we investigated heterozygous mouse mutants carrying the ASD-linked C456Y mutation of Grin2b, a high-confidence ASD risk gene encoding the GluN2B subunit of NMDA receptors. Comprehensive t...

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Autori principali: Zohreh Farsi, Ally Nicolella, Sean K. Simmons, Wangyong Shin, Muwon Kang, Gina Lee, Min Jee Kwon, Kira S. Brenner, Ines Picard, Nate Shepard, Deeksha Misri, Kira A. Perzel Mandell, Joshua Z. Levin, Eunjoon Kim, Morgan Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-02-01
Serie:iScience
Soggetti:
Molecular biology
Neuroscience
Systems biology
Accesso online:http://www.sciencedirect.com/science/article/pii/S2589004226000751
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