Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy

Summary: Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM biopsies. FGFR1 expression correlated with fibrosis...

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Detalhes bibliográficos

Principais autores:	Reo Hata, MD, Shunsuke Funakoshi, MD, PhD, Takeru Makiyama, MD, PhD, Takao Kato, MD, PhD, Megumi Narita, BS, Yasuko Matsumura, MS, Ryoko Hirohata, MS, Yuki Naka, BS, Kazumi Ida, MS, Hiroaki Ito, MD, Akihiko Yoshizawa, MD, PhD, Yasuhito Nannya, MD, PhD, Hironori Haga, MD, PhD, Seishi Ogawa, MD, PhD, Koh Ono, MD, PhD, Takeshi Kimura, MD, PhD, Yoshinori Yoshida, MD, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-10-01
coleção:	JACC: Basic to Translational Science
Assuntos:	cardiac fibrosis cardiac fibrosis organoid model dilated cardiomyopathy FGFR inhibition transcriptomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452302X2500316X
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