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Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

In previous work, we showed that intrinsically disordered regions (IDRs) of proteins contain sequence-distributed molecular features that are conserved over evolution, despite little sequence similarity that can be detected in alignments (Zarin et al., 2019). Here, we aim to use these molecular feat...

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Principais autores: Taraneh Zarin, Bob Strome, Gang Peng, Iva Pritišanac, Julie D Forman-Kay, Alan M Moses
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-02-01
coleção:eLife
Assuntos:
IDRs
lasso
IRLS
evolutionary signatures
logistic regression
Expectation-Maximization
Acesso em linha:https://elifesciences.org/articles/60220
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