A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium

Mutations in tripeptidyl peptidase 1 (TPP1) have been associated with late infantile neuronal ceroid lipofuscinosis (NCL), a neurodegenerative disorder. TPP1 is a lysosomal serine protease, which removes tripeptides from the N-terminus of proteins and is composed of an N-terminal prodomain and a cat...

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Auteurs principaux:	Maria Stumpf, Rolf Müller, Berthold Gaßen, Regina Wehrstedt, Petra Fey, Malte A. Karow, Ludwig Eichinger, Gernot Glöckner, Angelika A. Noegel
Format:	Artigo
Langue:	Inglês
Publié:	The Company of Biologists 2017-07-01
Collection:	Disease Models & Mechanisms
Sujets:	Neuronal ceroid lipofuscinosis (NCL) Tripeptidyl peptidase 1 (TPP1) Golgi pH regulator (GPHR) Endosomes Lysosomes
Accès en ligne:	http://dmm.biologists.org/content/10/7/897
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