Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

Abstract Background The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from CXCR4 (X4)-tropic HIV-1 infection, making CXCR4 an important target f...

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Principais autores:	Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, Zhepeng Liu, Shuai Liu, Panpan Hou, Li Zhou, Wei Hou, Wenzhe Ho, Chunmei Li, Li Wu, Deyin Guo
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2017-11-01
Serija:	Retrovirology
Teme:	CXCR4 HIV-1 Primary CD4+ T cells Adeno-associated virus CRISPR/SaCas9
Online dostop:	http://link.springer.com/article/10.1186/s12977-017-0375-0
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