Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol

Introduction Bipolar disorder affects around 2% of the population and is linked with reduced life expectancy and socioeconomic burden. Depressive episodes are difficult to treat and typically more prevalent, enduring and burdensome than manic episodes. The use of antidepressants alone has limited ef...

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Autors principals:	Andrea Cipriani, Michael Cole, Neil Nixon, John Gibson, David Kessler, Jonathan Evans, Thomas Kabir, Emma Clark, Judit Simon, Glyn Lewis, Richard Morris, Carolyn A Chew-Graham, Helen C Hancock, Firoza Davies, Stuart Watson, Fiona Turnbull, Keith Thompson, Lyndsey Dixon, Tania Gergel, Dennis Wienand, Faye Wolstenhulme, Sarah Al-Ashmori, Lumbini Azim, Chrissie Butcher, Emily Clare, Susanna Carella, Isobel Hoppe, Ayesha Mathias, Marion Dawn Teare, Mourad Wahba, Lauren Wall, Zoe Walmsley, Niraj Ahuja, Fiona Cammack, Caroline Kemp, Sally Keys, Sue Webster
Format:	Artigo
Idioma:	Inglês
Publicat:	BMJ Publishing Group 2026-03-01
Col·lecció:	BMJ Open
Accés en línia:	https://bmjopen.bmj.com/content/16/3/e112677.full
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