PmrA Mutations in Drug-Resistant <i>Acinetobacter baumannii</i> Affect Sensor Kinase-Response Regulator Interaction and Phosphotransfer

Multi-drug resistance in <i>Acinetobacter baumannii</i> poses a significant human health threat. For multidrug-resistant pathogens, ‘last line of defense’ antibiotics like the polymyxins are implemented. Concerningly, polymyxin-resistance is evidenced in <i>Acinetobacter baumannii</i> and is mediate...

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Detalhes bibliográficos

Principais autores:	Felicia E. Jaimes, Alexander D. Hondros, Jude Kinkead, Morgan E. Milton, Richele J. Thompson, Aimee M. Figg, Christian Melander, John Cavanagh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-11-01
coleção:	Microorganisms
Assuntos:	two-component systems antibiotic resistance response regulators point-mutants regulatory networks transcriptional control
Acesso em linha:	https://www.mdpi.com/2076-2607/13/11/2600
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