Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus

Recently, a S168T variant in the acetylcholine receptor subunit ACR-8 was associated with levamisole resistance in the parasitic helminth Haemonchus contortus. Here, we used the Xenopus laevis oocyte expression system and two-electrode voltage-clamp electrophysiology to measure the functional impact...

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Autores principales:	Alistair Antonopoulos, Claude L. Charvet, Kirsty Maitland, Stephen R. Doyle, Cédric Neveu, Roz Laing
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-04-01
Colección:	International Journal for Parasitology: Drugs and Drug Resistance
Materias:	Levamisole resistance S168T Haemonchus contortus Resistance mechanism Functional validation Acetylcholine receptor
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211320724000058
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