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Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate

Regulatory agencies encourage computer modeling and simulation to reduce the time and cost of clinical trials. Although still not classified in formal guidelines, system biology-based models represent a powerful tool for generating hypotheses with great molecular detail. Herein, we have applied a me...

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Principais autores: José Ramón Gutiérrez-Casares, Javier Quintero, Guillem Jorba, Valentin Junet, Vicente Martínez, Tamara Pozo-Rubio, Baldomero Oliva, Xavier Daura, José Manuel Mas, Carmen Montoto
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-11-01
coleção:Frontiers in Psychiatry
Assuntos:
attention-deficit/hyperactivity disorder
lisdexamfetamine
methylphenidate
mathematical modeling
in silico clinical trial
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.741170/full
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