Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism

Pancreatic cancer is a highly aggressive malignancy with a poor prognosis due to its complex tumor microenvironment (TME), which includes a dense extracellular matrix (ECM) and immunosuppressive pathways. Nanomedicine capable of achieving profound tumor penetration and modulating the tumor immune mi...

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Autori principali:	Meng Li, Danling Cheng, Yue Wang, Chongwen Xuan, Viktar Abashkin, Jindong Xia, Ling Ding, Jingchao Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-08-01
Serie:	Materials Today Bio
Soggetti:	Polymer nanoparticles Sonodynamic therapy Immunotherapy Orthotopic pancreatic cancer Tumor microenvironment
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2590006425005241
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