The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling

Abstract Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critical mediator of mechanotransduction, with its mechan...

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Autori principali:	Nourhan Hassan, Burkhard Greve, Martin Götte
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-06-01
Serie:	Cellular & Molecular Biology Letters
Soggetti:	Mechanotransduction Extracellular matrix Integrins Focal adhesion kinase YAP signaling Disease pathogenesis
Accesso online:	https://doi.org/10.1186/s11658-026-00905-z
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