Cyclin-dependent kinase inhibitor 1 plays a more prominent role than activating transcription factor 4 or the p53 tumour suppressor in thapsigargin-induced G1 arrest

Background Thapsigargin (Tg) is a compound that inhibits the SERCA calcium transporter leading to decreased endoplasmic reticulum (ER) Ca2+ levels. Many ER chaperones are required for proper folding of membrane-associated and secreted proteins, and they are Ca2+ dependent. Therefore, Tg leads to the...

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Principais autores:	Erin van Zyl, Claire Peneycad, Evan Perehiniak, Bruce C. McKay
Formato:	Artigo
Idioma:	Inglês
Publicado em:	PeerJ Inc. 2023-12-01
Colecção:	PeerJ
Assuntos:	Cell cycle ER stress Thapsigargin ATF4 CDKN1A TP53
Acesso em linha:	https://peerj.com/articles/16683.pdf
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