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Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling

The developmental plasticity of embryonic stem cells (ESCs) is mainly controlled by well-characterized transcription factors, but additional factors, especially those related to metabolism that modulate this intrinsic program remain elusive. Here, using whole transcriptome analysis, we identified br...

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Principais autores: Shaohui Chen, Bohan Chen, Guangsong Su, Jun Chen, Dianhao Guo, Qingqing Yin, Wenbin Wang, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Wange Lu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-12-01
Serier:Stem Cell Research
Fag:
Bcat1
Self-renewal
Pluripotency
Embryonic stem cells
Rasal1
Online adgang:http://www.sciencedirect.com/science/article/pii/S1873506120303986
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