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Targeting dengue through mucosal vaccination: the potential of NS1 and bacterial spore-based delivery platforms

Severe dengue is characterized by marked vascular leakage, hemorrhagic manifestations, and organ impairment, largely driven by immunopathological mechanisms. Traditional vaccine approaches focusing on inducing neutralizing antibodies against DENV structural antigens have shown limitations and, under...

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Hlavní autoři: Nurfatihah Zulkifli, Ok Sarah Shin, Sazaly AbuBakar
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-07-01
Edice:Frontiers in Immunology
Témata:
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1809605/full
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