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TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells

Summary: This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis that achieved similar exposures in the rat we...

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Principais autores: Faye Wang, Cindy Zhang, Jae Kwagh, Brian Strassle, Jinqing Li, Minxue Huang, Yunling Song, Brenda Lehman, Richard Westhouse, Kamalavenkatesh Palanisamy, Vinay K. Holenarsipur, Robert Borzilleri, Karen Augustine-Rauch
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-03-01
Serier:iScience
Fag:
molecular physiology
molecular biology
cell biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004221001012
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