Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics

Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fundamental role in cellular signalling. While ATP-c...

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Bibliografische Detailangaben

Hauptverfasser:	Laszlo Gyenis, Daniel Menyhart, Edward S. Cruise, Kristina Jurcic, Scott E. Roffey, Darren B. Chai, Flaviu Trifoi, Sam R. Fess, Paul J. Desormeaux, Teresa Núñez de Villavicencio Díaz, Adam J. Rabalski, Stephanie A. Zukowski, Jacob P. Turowec, Paula Pittock, Gilles Lajoie, David W. Litchfield
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-06-01
Schriftenreihe:	Frontiers in Molecular Biosciences
Schlagworte:	protein kinase CK2 CSNK2 chemical genetics CX-4945 phosphoproteomics SILAC
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.909711/full
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