P059 | SPLENOMEGALY IN DE NOVO ACUTE MYELOID LEUKEMIA IS ASSOCIATED WITH ASXL1 MUTATIONS AND PECULIAR GENE EXPRESSION AND CLINICAL PROFILE.

Splenomegaly is an event occurring in 10-40% of de novo acute myeloid leukemia (AML), recently linked to poorer prognosis. Studies in murine models have shown that loss of ASXL1 gene function leads to significant enlarged spleen volume, due to an increased infiltration of myeloid cells into the sple...

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Hauptverfasser:	F. Tarantini, N. Coccaro, C. Cumbo, I. Redavid, L. Anelli, A. Zagaria, E. Parciante, M.R. Conserva, G. Tota, C. F. Minervini, A. Minervini, A. Mestice, V.P. Gagliardi, M. Delia, P. Carluccio, I. Attolico, A. Ricco, M.G. Macchia, M.F. Caratozzolo, F. Marzano, C. Telegrafo, S.N. Cox, B. Balech, A. Tullo, G. Specchia, P. Musto, F. Albano
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Ferrata Storti Foundation 2025-09-01
Schriftenreihe:	Haematologica
Online-Zugang:	https://haematologica.org/article/view/12456
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