Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism

Proteins in either a native or denatured conformation often aggregate at an isoelectric point (pI), a phenomenon known as pI precipitation. However, only a few studies have addressed the role of pI precipitation in amyloid formation, the crystal-like aggregation of denatured proteins. We found that...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-01-01
Schriftenreihe:	Current Research in Structural Biology
Schlagworte:	Amyloid fibrils α-synuclein Isoelectric point precipitation Salting-out effects Nuclear magnetic resonance (NMR) Principal component analysis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2665928X20300040
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