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Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

Here, we determined the anti-neoplastic actions of formononetin (FT) against multiple myeloma (MM) and elucidated its possible mode of action. It was observed that FT enhanced the apoptosis caused by bortezomib (Bor) and mitigated proliferation in MM cells, and these events are regulated by nuclear...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Chulwon Kim, Jong Hyun Lee, Jeong-Hyeon Ko, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2019-07-01
Rangatū:Biomolecules
Ngā marau:
Formononetin
bortezomib
NF-κB
PI3K/AKT
AP-1
Urunga tuihono:https://www.mdpi.com/2218-273X/9/7/262
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