Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

Abstract Background Targeted alpha therapy (TAT) has emerged as a promising strategy for cancer treatment by selectively delivering high linear energy transfer (LET) alpha-emitters to tumor cells while minimizing off-target toxicity. However, the clinical translation of alpha-emitters, particularly...

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Bibliografische Detailangaben

Hauptverfasser:	Meng-Die Yang, Kang Fang, Xiao-Yi Zhang, Gang Yang, He-Qing Yi, Le Cai, Shan-Shan Qin, Xin-Da Yang, Rong Rong, Shuo Shi, Fei Yu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	KeAi Communications Co., Ltd. 2025-12-01
Schriftenreihe:	Military Medical Research
Schlagworte:	Targeted alpha therapy (TAT) Alpha-emitters Radium-223 (223Ra) Bioorthogonal click chemistry
Online-Zugang:	https://doi.org/10.1186/s40779-025-00673-5
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