Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response

IntroductionResistance to anti-HER2 therapies and incomplete response remain considerable challenges in managing HER2-positive tumors. Furthermore, some healthy organs, like the heart, express low levels of HER2, entailing a risk of toxic side effects, such as cardiotoxicity. Thus, the development o...

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Principais autores:	Chiara Cappello, Francesca Ruzzi, Julia Consoli, Maria Sofia Semprini, Laura Scalambra, Olga Maria Pittino, Stefania Angelicola, Arianna Palladini, Mette Thorn, Patrizia Nanni, Pier-Luigi Lollini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-11-01
coleção:	Frontiers in Pharmacology
Assuntos:	breast cancer HER2 anti-HER2 therapies in vitro preclinical models cross-reactivity studies
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1675875/full
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