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Improving the bioavailability of nintedanib by formulating inhalable ufasomes as a targeted therapy for non-small cell lung cancer

The safety and effectiveness of nintedanib in treating non-small cell lung cancer (NSCLC) have been evaluated in several clinical trials. However, nintedanib exhibits low oral bioavailability due to its poor solubility and first-pass metabolism. To enhance the sustainability, targeting, bioavailabil...

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Hoofdauteurs: Salman M. Ghazwani, Sami Alhazmi, Salhah M. Ghazwani, Hussam M. Shubaily, Ahmed M. Wafi, Naifa Alenazi, Marwa Qadri, Amal Naif Alshammari, Wedad Mawkili, Jobran M. Moshi, Zenat Khired, Salama A. Salama
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2026-06-01
Reeks:International Journal of Pharmaceutics: X
Onderwerpen:
Lung cancer
Lewis lung carcinoma
Targeting
Nintedanib
Bioavailability
Online toegang:http://www.sciencedirect.com/science/article/pii/S2590156725001677
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