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NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development

Abstract Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 complex to collaboratively promote rDNA transcription via triggering the directly binding of NF45/NF90 to the ARRE2‐like sequences in rDNA promoter...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Zhao, John E Eriksson, Wenbin Deng, Fang Cheng, Hongbo Chen
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Springer Nature 2021-02-01
Rangatū:EMBO Molecular Medicine
Ngā marau:
CX5461
NF45/NF90
NFAT
nucleolus
organ transplantation
Urunga tuihono:https://doi.org/10.15252/emmm.202012834
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