Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer

Abstract Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who presented with high-grade primary prostate cancer...

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Hauptverfasser:	Hannah E. Bergom, Laura A. Sena, Abderrahman Day, Benjamin Miller, Carly D. Miller, John R. Lozada, Nicholas Zorko, Jinhua Wang, Eugene Shenderov, Francisco Pereira Lobo, Fernanda Caramella-Pereira, Luigi Marchionni, Charles G. Drake, Tamara Lotan, Angelo M. De Marzo, Justin Hwang, Emmanuel S. Antonarakis
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-01-01
Schriftenreihe:	npj Genomic Medicine
Online-Zugang:	https://doi.org/10.1038/s41525-024-00392-1
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