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Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease

Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine kinase that is activated following an increase in the intracellular Ca2+ concentration and activates multiple signaling cascades that control physiologically important neuronal processes. CaMKK2 has been implicated in s...

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Autor principal: Mohammad Golam Sabbir
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
transferrin
CaMKK2
phosphorylation
alzheimer's disease
trafficking
cerebrospinal fluid
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmolb.2018.00099/full
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