Immune–tumor cell ligand–receptor axes driving metabolic reprogramming and therapeutic resistance in cancer

Therapeutic resistance remains a major barrier to durable cancer control and cannot be fully explained by tumor-intrinsic genetic and epigenetic alterations alone. Increasing evidence indicates that resistance emerges within a dynamic tumor microenvironment in which immune cells actively instruct tu...

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Главные авторы:	Hailin Zhu, Wang Yi, Yujie Wu, Rong Li, Boxuan Zhou
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-06-01
Серии:	Frontiers in Immunology
Предметы:	drug resistance immune checkpoint immune–tumor communication lactate signaling ligand–receptor axis metabolic reprogramming
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1864068/full
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