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B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction

Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction. B cells have restricted cytoplasmic space, mainly occupied by a large nucleus, y...

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Autori principali: Romina Ulloa, Oreste Corrales, Fernanda Cabrera-Reyes, Jorge Jara-Wilde, Juan José Saez, Christopher Rivas, Jonathan Lagos, Steffen Härtel, Clara Quiroga, María-Isabel Yuseff, Jheimmy Diaz-Muñoz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-02-01
Serie:Frontiers in Immunology
Soggetti:
B cells
nuclear morphology
immune synapse
actin cytoskeleton
Nesprin-1
Sun-1
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2021.801164/full
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