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MHY498 Nanosuspensions for Improved Topical Drug Delivery: Understanding of Its Solubility Behavior in DEGME + Water Mixtures and Preparation of Nanosuspension Using Box–Behnken Design

<b>Background/Objectives</b>: MHY498, a tyrosinase inhibitor, exhibits poor water solubility, which limits its topical delivery. Despite the importance of solubility data in rational formulation design, comprehensive information on its solubility behavior in various solvents and across a range of te...

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Main Authors: Eun-Sol Ha, Ha Nim Lee, Seon-Kwang Lee, Ji-Su Jeong, Jeong-Soo Kim, Hyung Ryong Moon, In-hwan Baek, Heejun Park, Min-Soo Kim
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-01-01
Series:Pharmaceutics
Subjects:
MHY498
solubility
correlation
antisolvent precipitation
nanosuspension
Online Access:https://www.mdpi.com/1999-4923/18/1/127
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