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Mechanistic insights of hypoglycemic components from Polygonatum polysaccharide

BackgroundThis study aimed to fractionate Polygonatum cyrtonema polysaccharide (PP) into distinct components, evaluate their hypoglycemic efficacy using both in vitro and in vivo models, and elucidate the mechanisms of the most active fraction.MethodsThree polysaccharide fractions (PP I, PP II, PP I...

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Uloženo v:
Hlavní autoři: Zeming Ren, Sisi Chen, Zhongxiu Guo, Xiyu Mei, Yeling Tong, Yane Liu, Ziyun Gao, Xuan Chen, Guanhai Dai
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-03-01
Edice:Frontiers in Endocrinology
Témata:
gluconeogenesis
hypoglycemic
leptin
Polygonatum cyrtonema polysaccharide III
short-chain fatty acids
type 2 diabetes mellitus
On-line přístup:https://www.frontiersin.org/articles/10.3389/fendo.2026.1744730/full
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