Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of...

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Váldodahkkit:	Marcelo Vizoná Liberato, Alessandro S Nascimento, Steven D Ayers, Jean Z Lin, Aleksandra Cvoro, Rodrigo L Silveira, Leandro Martínez, Paulo C T Souza, Daniel Saidemberg, Tuo Deng, Angela Angelica Amato, Marie Togashi, Willa A Hsueh, Kevin Phillips, Mário Sérgio Palma, Francisco A R Neves, Munir S Skaf, Paul Webb, Igor Polikarpov
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Public Library of Science (PLoS) 2012-01-01
Ráidu:	PLoS ONE
Liŋkkat:	http://europepmc.org/articles/PMC3359336?pdf=render
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