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Metastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia

Abstract Background Immune checkpoint blockade (ICB) elicits a strong and durable therapeutic response, but its application is limited by disparate responses and its associated immune-related adverse events (irAEs). Previously, in a murine model of lymph node (LN) metastasis, we showed that intranod...

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Главные авторы: Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2023-06-01
Серии:Journal of Experimental & Clinical Cancer Research
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Online-ссылка:https://doi.org/10.1186/s13046-023-02645-w
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