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Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents

In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and studied. Chloramphenicol amine (CAM), derived from th...

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Autors principals: Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2022-12-01
Col·lecció:Antibiotics
Matèries:
chloramphenicol
berberine
C-13 derivatives of berberine
bacterial ribosome
bacterial membrane potential
antibiotic activity
Accés en línia:https://www.mdpi.com/2079-6382/12/1/15
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