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Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis

Abstract Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly elevated GSDMD in human and mouse LN kidneys, predominantly in CD11b+ myeloid cells. Global or myeloid-conditional de...

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Wedi'i Gadw mewn:
Prif Awduron: Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Jing Nie, Ning Luo, Xiaoyan Li, Wei Chen, Haiping Mao, Yi Zhou, Xueqing Yu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2024-06-01
Cyfres:Cell Communication and Signaling
Pynciau:
Gasdermin D
Lupus nephritis
Myeloid cell
Granulopoiesis
Calcium influx
Mynediad Ar-lein:https://doi.org/10.1186/s12964-024-01681-z
Tagiau: Ychwanegu Tag
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