Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering

CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized. In recent years, extensive studies have been conducted to improve the gene-editing specificity...

Descripción completa

Detalles Bibliográficos

Autores principales:	Xiaoqiang Huang, Dongshan Yang, Jifeng Zhang, Jie Xu, Y. Eugene Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-07-01
Colección:	Cells
Materias:	gene editing CRISPR–Cas9 off-target specificity high fidelity protein engineering
Acceso en línea:	https://www.mdpi.com/2073-4409/11/14/2186
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!