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First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial

Background Luminal B breast cancer (BC) presents a worse prognosis when compared with luminal A BC and exhibits a lower sensitivity to chemotherapy and a lower immunogenicity in contrast to non-luminal BC subtypes. The Neo-CheckRay clinical trial investigates the use of stereotactic body radiation t...

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Hlavní autoři: Martine Piccart-Gebhart, Emanuela Romano, Christos Sotiriou, Marianne Paesmans, Ligia Craciun, Denis Larsimont, Roberto Salgado, Elisa Agostinetto, Laurence Buisseret, Isabelle Veys, Alex de Caluwé, Philip Poortmans, Andrea Gombos, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Dirk Van Gestel, Michail Ignatiadis
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2023-12-01
Edice:Journal for ImmunoTherapy of Cancer
On-line přístup:https://jitc.bmj.com/content/11/12/e007279.full
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