Overexpression of CD6 and PD-1 Identifies Dysfunctional CD8+ T-Cells During Chronic SIV Infection of Rhesus Macaques

Effective CD8+ T-cell responses play an important role in determining the course of SIV/HIV viral infection. Here we identified a unique population of dysfunctional CD8+ T-cells in lymphoid tissues and bronchoalveolar lavage (BAL) of rhesus macaques with chronic SIV infection characterized by co-exp...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Gospel Enyindah-Asonye, Anthony Nwankwo, Mohammad Arif Rahman, Ruth Hunegnaw, Christopher Hogge, Sabrina Helmold Hait, Eun-Ju Ko, Tanya Hoang, Marjorie Robert-Guroff
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-01-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	rhesus macaque simian immunodeficiency virus T-cell exhaustion CD6 PD-1
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fimmu.2019.03005/full
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