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A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer’s Disease

In Alzheimer’s disease (AD), both cholesterol and glucose dysmetabolism precede the onset of memory deficit and contribute to the disease’s progression. It is indeed now believed that oxidized cholesterol in the form of oxysterols and altered glucose uptake are the main triggers in AD affecting prod...

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Principais autores: Paola Gamba, Erica Staurenghi, Gabriella Testa, Serena Giannelli, Barbara Sottero, Gabriella Leonarduzzi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-05-01
Serier:Frontiers in Neuroscience
Fag:
Alzheimer’s disease
cholesterol metabolism
oxysterols
glucose metabolism
insulin resistance
renin-angiotensin system
Online adgang:https://www.frontiersin.org/article/10.3389/fnins.2019.00556/full
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