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Functional dissection of the prototype foamy virus glycoprotein heparan sulfate binding site

Abstract Background The foamy virus (FV) glycoprotein complex (GPC) facilitates exceptionally broad species and tissue tropism. While cell surface heparan sulfate (HS) serves as a known attachment factor, it is not essential for viral entry. Recent high-resolution structures of GPCs from various FV...

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Bibliographic Details
Main Authors: Max Büttrich, Nicole Stanke-Scheffler, Thomas Calcraft, Peter B. Rosenthal, Dirk Lindemann
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Retrovirology
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Online Access:https://doi.org/10.1186/s12977-026-00676-7
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