Pleurotus ostreatus ethanolic extract exerts anti-cancer effects via PI3K/Akt/mTOR pathway modulation in DMBA-NMU induced breast cancer in female Sprague Dawley rats

Hormone receptor–positive Breast Cancer (BC) driven by PI3K/Akt/mTOR signaling remains a major therapeutic challenge, particularly in settings where conventional chemotherapy causes severe systemic and reproductive toxicity. This study evaluated the antitumor and chemopreventive efficacy of Pleurotu...

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Autors principals:	Magdalene Eno Udobi, Israel Sunmola Afolabi, Cynthia Nwamaka Ikeji, Ebenezer Olatunde Farombi, Shalom Nwodo Chinedu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-04-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	anti-cancer antioxidant status breast cancer chemoprevention DMBA-NMU model female rats
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1766536/full
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