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A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase I

Background: Inhibition of human topoisomerase I (TOP1) by camptothecin and topotecan has been shown to reduce excessive transcription of PAMP (Pathogen-Associated Molecular Pattern)-induced genes in prior studies, preventing death from sepsis in animal models of bacterial and SARS-CoV-2 infections....

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Principais autores: Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai, Christopher Mederos, Purushottam B. Tiwari, Aaron Z. Welch, Yuk-Ching Tse-Dinh
Formato: Artigo
Idioma:Inglês
Publicado em: IMR Press 2022-03-01
coleção:Frontiers in Bioscience-Landmark
Assuntos:
human top1
topoisomerase inhibitor
sepsis
inflammation
yeast-based screening system
Acesso em linha:https://www.imrpress.com/journal/FBL/27/3/10.31083/j.fbl2703093
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