JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET protein association to histone H4-hyperacetylate...

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Podrobná bibliografie

Hlavní autoři:	Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2018-04-01
Edice:	Epigenetics
Témata:	bet brd2 cage h4 hyperacetylation jq1
On-line přístup:	http://dx.doi.org/10.1080/15592294.2018.1469891
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