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Differential roles of FOXC2 in the trabecular meshwork and Schlemm’s canal in glaucomatous pathology

FOXC2 is required in the Schlemm’s canal endothelium and neural crest-derived trabecular meshwork cells for the morphogenesis and maintenance of Schlemm’s canal. Impaired development and maintenance of Schlemm’s canal (SC) are associated with perturbed aqueous humor outflow and intraocular pressure....

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Bibliografische Detailangaben
Hauptverfasser: Naoto Ujiie, Pieter R Norden, Raymond Fang, Lisa Beckmann, Zhen Cai, Junghun Kweon, Ting Liu, Can Tan, Megan S Kuhn, W Daniel Stamer, Kazushi Aoto, Susan E Quaggin, Hao F Zhang, Tsutomu Kume
Format: Artigo
Sprache:Inglês
Veröffentlicht: Life Science Alliance LLC 2023-09-01
Schriftenreihe:Life Science Alliance
Online-Zugang:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201721
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