Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS

Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy....

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Principais autores:	T. A. Rodina, E. S. Melnikov, A. V. Sokolov, A. B. Prokofiev, V. V. Arkhipov, G. V. Adamov, D. L. Pozdnyakov, Yu. V. Olefir
Formato:	Artigo
Idioma:	Russo
Publicado em:	Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2018-02-01
coleção:	Регуляторные исследования и экспертиза лекарственных средств
Assuntos:	carbamazepine carbamazepine-10,11-epoxyde therapeutic drug monitoring trigeminal neuralgia hplc-ms/ms карбамазепин карбамазепин-10,11-эпоксид терапевтический лекарственный мониторинг невралгия тройничного нерва вэжх-мс/мс
Acesso em linha:	https://www.vedomostincesmp.ru/jour/article/view/60
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