Computational study of chalcone-cyanopyrimidine hybrids as LSD1 inhibitors: Assessing the influence of FAD on binding affinity and inhibition

The inhibition of lysine-specific demethylase 1 (LSD1) has emerged as a promising therapeutic strategy for cancer treatment due to its critical role in epigenetic regulation. In this study, we conducted an in-silico investigation to explore the potential of chalcone-cyanopyrimidine hybrids as LSD1 i...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Md Khalid Saifullah, Amisha Gupta, Darakhshan Parveen, Faizul Azam, M. Mumtaz Alam, Mymoona Akhter, Suhel Parvez, Naazneen Maksud, Naila Azeez, M. Shaquiquzzaman
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2025-12-01
Sarja:	Biochemistry and Biophysics Reports
Aiheet:	Cancer Lysine specific demethylase 1 Pyrimidine Chalcone Molecular docking Molecular dynamics
Linkit:	http://www.sciencedirect.com/science/article/pii/S2405580825004613
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