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De novo production of lacto-N-neotetraose by metabolic engineering of Saccharomyces cerevisiae as a cell factory

Lacto-N-neotetraose (LNnT) is a crucial neutral core human milk oligosaccharide (HMO). In this study, we established a LNnT-producing Saccharomyces cerevisiae cell factory through comprehensive metabolic engineering. Specifically, the de novo biosynthetic pathway of LNnT was assembled by heterologou...

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Hlavní autoři: Han Liu, Yingjie Liu, Haitao Hu, Chenlu Zhu, Shuang Zhang, Xiaomei Lyu, Ruijin Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: Tsinghua University Press 2026-02-01
Edice:Food Science and Human Wellness
Témata:
lacto-n-neotetraose
saccharomyces cerevisiae
gal system
modular engineering
On-line přístup:https://www.sciopen.com/article/10.26599/FSHW.2024.9250342
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