Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti‐Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation

Abstract The increased levels of cyclic nucleotides (cGMP and cAMP) in enterocytes trigger intracellular mechanisms of ion and fluid secretion into the lumen, causing secretory diarrhea. Twelve novel pyridopyrimidines derived from 5‐(3,5‐bistrifluoromethylphenyl)‐1,3‐dimethyl‐5,11‐dihydro‐1H‐indeno[...

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Hlavní autoři:	Dr. Tiago Zaminelli, Dr. Elisa Magli, Prof. Francesco Frecentese, Dr. Caroline H. Lescano, Dr. Rafael Campos, Dr. Irene Saccone, Dr. Angela Corvino, Dr. Paola Di Vaio, Dr. Flavia Giordano, Dr. Paolo Luciano, Prof. Ferdinando Fiorino, Prof. Elisa Perissutti, Prof. Vincenzo Santagada, Prof. Beatrice Severino, Prof. Giuseppe Caliendo, Prof. Gilberto De Nucci
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley-VCH 2019-04-01
Edice:	ChemistryOpen
Témata:	pyridopyrimidines diarrhea cyclic nucleotides drug discovery structure-activity relationships
On-line přístup:	https://doi.org/10.1002/open.201900060
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