Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found server matrix degradation and increased expression o...

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Dades bibliogràfiques

Autors principals:	Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Jin
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2024-05-01
Col·lecció:	eLife
Matèries:	hemophilic arthropathy DNA methylation tenascin XB cartilage degeneration chondrocyte apoptosis
Accés en línia:	https://elifesciences.org/articles/93087
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