Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus

Objectives Our current understanding of the genetic architecture of childhood-onset SLE (cSLE) is limited by a dearth of comprehensive genomic studies in cSLE. We have quantified the number of known rare and common SLE risk variants in a diverse cSLE cohort. We characterised type I interferon (IFN)...

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Autori principali:	Mariana J Kaplan, Sarfaraz Hasni, Ivona Aksentijevich, Earl D Silverman, Shajia Lu, Massimo Gadina, Michael J Ombrello, Diana Gómez-Martín, Christiaan Scott, Ana Barrera-Vargas, Zuoming Deng, Laura Lewandowski, Linda Hiraki, Jorge Romo Tena, Anthony M Musolf, Subrata Paul, Daniel Hupalo, Clifton L Dalgard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMJ Publishing Group 2025-06-01
Serie:	Lupus Science and Medicine
Accesso online:	https://lupus.bmj.com/content/12/1/e001475.full
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